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New Cancer Research Funding for Local Scientist

Wednesday, March 29, 2006

 

Click to listen to this page using ReadPlease Today, the Northern Cancer Research Foundation (NCRF) granted $215,000 to a research scientist in the Cancer Care wet lab at the Thunder Bay Regional Health Sciences Centre (TBRHSC).


New Cancer Research Funding

Dedicated completely to Northwestern Ontario, the NCRF provides funding to improve the research and successful collaborations with other leading centres, treatment, and patient education and awareness. With the grants provided, the cancer program can enhance service through new treatment and diagnostic equipment, and create social marketing campaigns to increase awareness around diseases like colorectal and prostate cancer. “In the more than ten years since the NCRF was created, the cancer research program has grown exponentially,” said Glenn Craig, President and CEO of the NCRF. “We provided the initial funding for the research wet lab at the cancer centre in 1997, stimulating the interest and activity in cancer research in our region. This growth has enabled us to attract the calibre of scientists like Dr. Zehbe. We are pleased to contribute $215,000 towards her research, in hopes that it brings her team closer to their goals.”

New Cancer Research Funding

Dr. Ingeborg Zehbe joined the cancer centre research team nearly a year ago from Mainz, Germany, where she had developed an area of expertise in the field of tumour biology. Her primary focus falls to the study of the Human Papilloma Virus (HPV), the prime risk factor in cervical cancer. She, along with her local co-authors Dr. Nick Escott, and Dr. Glen Holloway, at the Thunder Bay Regional Health Sciences Centre (TBRHSC) are concentrating on studying cervical cancer caused by HPV. One of the bases of their study is that a strong immune system is essential to fight micro-organisms, disease, and cancer. Taking it a step further, they are focusing their study on the production of a type of proteins, called cytokines, in women who are treated for abnormal PAP smears. “My focus has been on HPV for a number of years now,” stated Dr. Zehbe. “With this funding from the NCRF, we have begun a control group of blood samples from women attending the colposcopy lab under the care of Dr. Holloway and Dr. Escott. With these contributing results, we can determine, with all factors equal, why some women develop cervical cancer and some do not.”


The proteins, or cytokines, are vital for the woman’s immune system in helping specialized white blood cells to fight transformed cells before they develop from “pre-cancerous” into cancer. The ultimate goal of the research project is to measure cytokines in women with “pre-cancer” to determine if something is amiss with their immune system. The study hypothesizes that women with a well functioning immune system are more able to fight cervical cancer than women whose immune system is impaired. They expect to be able to apply this to the study and diagnosis of other tumour types, using the knowledge obtained from this study to improve prognosis and cancer therapy, specifically within immune therapy. Immune therapy is an individual form of cancer treatment using cells from the tumour patient which are “remodelled” or “engineered” outside the body (“ex vivo”) and thereafter donated back to the patient to perform tumour-killing actions.

 

Dr. Zehbe holds the distinction of being the first member of ICR Discoveries, the cancer research initiative in Northwestern Ontario and collaboration between TBRHSC, Lakehead University, and the Northern Ontario School of Medicine.

New Cancer Research Funding

ICR Discoveries is only one of the partnerships that the cancer centre and TBRHSC continues to establish and pursue. In the past few years, provincial, national, and global partnerships have been established and proposed, with most evolving through the research pillar of the cancer program. “Our research program continues to explore unique opportunities for teaching, research, and education; especially in light of the way our system is changing the way we treat people,” said Michael Power, Vice President of Regional Cancer and Diagnostics. “Over the last five years, our research scientists have secured nearly five million dollars in local and national grant funding, establishing a distinct foundation for cancer research growth and development.”


The NCRF and Regional Cancer Care are very pleased to be leading this announcement into April, which is Cancer Awareness Month. There are numerous activities designed to educate, generate awareness, promote research, and provide information on treatment and activity at Regional Cancer Care. Look for the flags flying, the commercials, the newspaper, and keep an eye out for the activities for the community to participate in all month long. As always, and as further exemplified by today’s announcement, all funds raised by the NCRF are 100% dedicated to supporting excellence in cancer care in Northwestern Ontario.

 

 

Dr. Ingeborg Zehbe Research Summary

 

Cancer Research Overview

 

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